Which is a contraindication for the administration of tissue plasminogen activator (t-pa)?5/20/2023 ![]() About an hour into treatment, the patient becomes significantly less responsive. With the patient's significant deficits, you decide to unsheathe the double-edged sword of tissue plasminogen activator (tPA). Naturally you get a CT, which shows no bleeding, but displays a dense right MCA (Image 1). On your next shift, you find yourself evaluating a 58-year-old-male with acute onset of left upper and lower extremity weakness and a facial droop that started 2 hours ago.
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